Skip to main content

Organic Pharmaceutical Chemistry

DRUGS and PHARMACEUTICALS

Analgesic Drugs

                An analgesic or pain killer is any member of the group of drugs used to achieve analgesia , relief from pain. The English word for pain is derived form the old French word 'piene' , Latin word 'poene' and Ancient Greek word 'poine'.

Causes Of Pain:

Following can be the reasons for any kind of pain;
  • Stress
  • Tension 
  • Coldness
  • Lack of Oxygen
  • Hotness
  • Carrying heavy loads 

Definition Of Analgesics

            These are the class of compounds which relief the pain without the production of unconsciousness. 
There action may 
  • Peripheral 
  • Central 
  • Peripheral + Central 

Classification On The Basis Of Cause Of Pain 

On the basis of cause of pain the compounds are classified the following two classes 

  1.  True Analgesics: Those compounds which relief the pain may or may not be affecting the cause of pain called True Analgesics.  
  2. False Analgesics : Those compounds which relief the pain by indirect action of reducing or removing the cause of the pain called False Analgesics. 

Classification On The Basis Of Mode Of Action

These compounds are also classified on the basis of mode of action . These are 

  1. Narcotic Analgesic ( Addiction ) Mode of action is Central
  2. Non-Narcotic Analgesics ( Non- Addiction ) Mode of action is Central + Peripheral 

Difference Between Anesthetic and Analgesics 

  • ANESTHETIC produce loss of sensation by blocking the conduction of pain impulse.
  • ANALGESICS decrease the perception of pain impulse , it do not block the pain stimulant.


Comments

Popular posts from this blog

Phenol-Formaldehyde Resin

Phenol formaldehyde resins (PF) or phenolic resins are synthetic polymers obtained by the reaction of phenol or substituted phenol with formaldehyde. Used as the basis for Bakelite, PFs were the first commercial synthetic resins (plastics). They have been widely used for the production of molded products including billiard balls, laboratory countertops, and as coatings and adhesives. They were at one time the primary material used for the production of circuit boards but have been largely replaced with epoxy resins and fiberglass cloth, as with fire-resistant FR-4 circuit board materials. There are two main production methods. One reacts phenol and formaldehyde directly to produce a thermosetting network polymer, while the other restricts the formaldehyde to produce a prepolymer known as novolac which can be moulded and then cured with the addition of more formaldehyde and heat. There are many variations in both production and input materials that are used to produce a wide variety

Urea-Formaldehyde Resin

Urea-formaldehyde , also known as   urea-methanal, so named for its common synthesis pathway and overall structure,is a   non-transparent   thermosetting   resin   or   polymer. It is produced from   urea   and   formaldehyde. These resins are used in   adhesives, finishes,   particle board,   MDF, and molded objects. It was first synthesized in 1884 by Hölzer, who was working with Bernhard Tollens. In 1919, Hanns John (1891–1942) of Prague, Czechoslovakia obtained the first patent for urea-formaldehyde resin. UF and related amino resins are a class of   thermosetting resins   of which urea-formaldehyde resins make up 80% produced globally. Examples of amino resins use include in automobile tires to improve the bonding of rubber to tire cord, in paper for improving tear strength, in molding electrical devices, jar caps, etc Urea-formaldehyde resin's attributes include high tensile strength, flexural modulus, and a high heat distortion temperature, low water absorption,

Antibiotics

The term antibiotics is a broad one , defined by Waksman as, "a substance produced by microorganisms , which has the capacity of inhibiting the growth and even of destroying other microorganisms by the action of very small amounts of the antibiotics " . Approximately 3000 substances come under the classification , but only 70 have the necessary combination of patient safety , antimicrobial action and stability. Penicillin, erythromycin, tetracycline, cephalosporins are among the most widely used. Penicillin : A number of penicillin, differing only in the composition of the R ( alkyl ) group, have been isolated from natural media and hundreds have been semi-synthesized . Penicillin G USP, with benzyl for R group, generally the most desirable , is the type commercially available , usually combined in salt form with procaine or potassium.  It is possible to assist the synthesis of a desired penicillin by supplying the appropriate precursor to the culture i.e., the acid of