Learning Chemistry

Preparation of Aspirin from Salicylic acid Aspirin Acetyl Salicylic acid also known as aspirin , is one of the most widely used medication to reduce fever and also used as pain killer . It is an acetyl derivative of Salicylic acid . It is white in colour , crystalline in shape, weakly acidic substance which melts at 135 Celsius . Theory Aspirin is synthesised through the reaction of Salicylic acid with acetic anhydride which turns salicylic acid's hydroxyl group into an acetyl group . A white , milky structure was obtained when Salicylic acid , acetic anhydride and sulphuric acid ( a catalyst ) were mixed .  the mechanism of the reaction is  In the first part of the experiment , Salicylic acid was heated so that it would melt and react with acetic anhydride .  Sulphuric acid is added as a catalyst . it is strong acid so there are many available protons. the synthesis is acid catalysed.  First there is a reversible reaction in which the the oxyge...

Antipyretic Analgesics: Salicylates     ( e.g. Aspirin, Methyl salicylates ) Acetanalide ( e.g. Paracetamol , known in the US as acetaminophen or simply APAP ) Anthranilic acid derivatives ( e.g. Ponstan )  Opioid drugs such as morphine and oxycodone  Salicylates: Salicylic acid it self used as potent analgesic but has gastric irritation so the derivative of salicylic acid are produced to reduce the gastric toxicity . Derivative of salicylic acid are the salts of carboxyl group as well as acetyl derivative of salicylic acid. Aspirin ( Acetyl salicylic acid , Dispirin ) Methyl salicylates ( Wintogeno balm ) Aspirin: ( Acetyl Salicylic acid ) Brand name : Dispirin Active Ingredient : Aspirin IUPAC name : Methyl 2- hydroxybenzoate Molecular formula : C 8 H 8 O 3 Structural formula of Dispirin : Aspirin + Na -citrate + NaHCO 3 Synthesis:retic analgesics                        ...